Vaccine_2

Vials labelled “Astra Zeneca COVID-19 Coronavirus Vaccine” and a syringe are seen in front of a displayed AstraZeneca logo, in this illustration photo taken March 14, 2021.

  • Variants may cause few breakthrough infections in vaccinated
  • Researchers find no evidence of widespread virus escape
  • Past infection with B117/Alpha confers broad protection

June 22 (Reuters) - COVID-19 vaccines made by AstraZeneca (AZN.L) and the Pfizer-BioNTech (PFE.N)(22UAy.DE) alliance remain broadly effective against Delta and Kappa variants of the COVID-19 causing virus, which were first identified in India, according to a scientific study, underpinning a continued push to deliver the shots.

The study by Oxford University researchers, published in the journal Cell, investigated the ability of antibodies in the blood from people, who were vaccinated with the two-shot regimens, to neutralize the highly contagious Delta and Kappa variants, a statement said.

"There is no evidence of widespread escape suggesting that the current generation of vaccines will provide protection against the B.1.617 lineage," the paper said, referring to the Delta and Kappa variants by a commonly used code.

However, the concentration of neutralising antibodies in the blood was somewhat reduced, which may lead to some breakthrough infections, they cautioned.

Last week, an analysis by the Public Health England (PHE) showed that vaccines made by Pfizer and AstraZeneca offer high protection of more than 90% against hospitalization from the Delta variant. 

"We are encouraged to see the non-clinical results published from Oxford and these data, alongside the recent early real-world analysis from Public Health England, provide us with a positive indication that our vaccine can have significant impact against the Delta variant," AstraZeneca executive Mene Pangalos said in a separate statement.

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Vials labelled "Astra Zeneca COVID-19 Coronavirus Vaccine" and a syringe are seen in front of a displayed AstraZeneca logo, in this illustration photo taken March 14, 2021. REUTERS/Dado Ruvic

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The Oxford researchers also analysed the likelihood of reinfection in people who had previously had COVID-19.

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Looking at the ability of antibodies in their blood samples to neutralize the variants, the risk of reinfection with the Delta variant appeared particularly high in individuals previously infected by the Beta and Gamma lineages that emerged in South Africa and Brazil, respectively.

By contrast, previous infection with the Alpha, or B117, variant first detected in Britain, conferred "reasonable" cross-protection against all variants of concern, lending itself as a template that next-generation vaccines could be molded on.

"B117 might be a candidate for new variant vaccines to provide the broadest protection," the researchers said.

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